[Cell Metabolism] May 2010's Featured Reviews: Focus on Brown Adipocytes

http://tinyurl.com/ykqntcj
The Top 10 Everything of 2009
TIME charts the highs and lows of the past year in 50 wide-ranging lists

Top 10 Medical Breakthroughs
10. Brown Fat in Adults




Why the Physiology textbook tell us WAT for storage energy, BAT for thermogenesis?

If they are all "adipose tissue", why they behaved so different (← one for storage fat, one for burn fat??)




Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev. 1991 Sep;5(9):1513-23.

→ I like these two great pictures-
Spatial patterns of expression resulting from promoter trap events. Embryos from different strains and stages were stained with X-gal to reveal B-gal activity. Thus we can see the promoter expression in every stages in mouse prenatal development.



Brown adipose tissue: function and physiological significance. Physiol Rev. 2004 Jan;84(1):277-359.


→ Prof. Dr. Barbara Cannon is very famous in Lipids filed. I like this BAT review paper very much!!


In 2007, Prof. Dr. Barbara Cannon had an invited review published in Am J Physiol Endocrinol Metab.


→ To see the PET demo, click this link:
http://www.med.harvard.edu/JPNM/chetan/normals/brown_fat/case.html

&

Molecular determinants of brown adipocyte formation and function. Genes Dev. 2008 May 15;22(10):1269-75.

Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev. 2008 May 15;22(10):1397-409.

PRDM16 controls a brown fat/skeletal muscle switch. Nature. 2008 Aug 21;454(7207):961-7.



finally..

Developmental biology: Neither fat nor flesh. Nature. 2008 Aug 21;454(7207):947-8.


"In mammals, white adipose tissue stores fat, whereas brown adipose tissue burns fat. Brown adipocytes have a common origin with muscle cells, which could help explain their unusual function."




http://www.the-aps.org/meetings/eb10/abs/ceps-sweazea.htm

Comparative Metabolic Physiology
Sponsored by the APS Animal Care Committee
Hypoxia and Oxidative Stress and Thermoregulation and Environmental Stress Tracks


Tuesday, April 27 � 3:15 PM-5:45 PM
Anaheim Convention Center, Room 303D

Chaired:
Karen Sweazea, Arizona State Univ.





Cell Metabolism

Volume 11, Issue 5: May 5, 2010
Next issue: June 9, 2010

Featured Reviews  free

Focus on Brown Adipocytes

Editorial

Brown Adipocyte Focus

Emambokus and Wang

Minireviews

Human Brown Adipose Tissue
Enerbäck
Distribution and Development of Brown Adipocytes in the Murine and Human Adipose Organ
Frontini and Cinti
Transcriptional Control of Brown Fat Development
Kajimura et al.
Brown Fat and the Myth of Diet-Induced Thermogenesis
Kozak
The Changed Metabolic World with Human Brown Adipose Tissue: Therapeutic Visions
Nedergaard and Cannon

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